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Protandim

NAD Synergizer™

60 Capsules

Protandim® NAD Synergizer was specifically formulated to target NAD, and has been shown to double sirtuin activity in 24 hours. Supporting increased health, focus, energy, mental clarity, and mood. *

Beyond NAD

Recently, scientists have been sharing the immense importance of proteins called sirtuins. Studies are showing sirtuin activity comes with a cascade of health benefits. Including supporting a healthy vascular system, maintaining cholesterol levels already in the healthy range, supporting the body’s healthy inflammatory response, supporting joint health, heightening mental focus, improving mood, motivation, energy, and much more. However sirtuin activity declines as we age (≃60%).

Researchers have discovered that sirtuin activity can be increased through drastic caloric restriction (reducing calories by 40-60%). A typical caloric restriction diet can increase sirtuin activity 94%. Obviously this drastic approach runs the risk of nutrient deficiency and is not recommended without medical supervision.

So, with the knowledge that sirtuin activation requires the molecule NAD, we went to work. Protandim® NAD Synergizer was specifically formulated to target NAD, and has been shown to double sirtuin activity in 24 hours, supporting increased health, focus, energy, mental clarity, and mood. *

Benefits

Supports healthy longevity*
Supports autophagy (removal of cellular waste)*
Improves mental focus and concentration*
Supports positive mood and motivation*
Boosts mental and physical energy*
Supports body's healthy inflammatory response*
Maintain cholesterol levels already in the healthy range*
Supports healthy vascular system*

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent disease.

Cell signaling pathways are essential for your survival and your health—both short- and long-term.

When you are young, these cell signaling pathways work well, respond quickly, and allow you to robustly adapt to whatever your environment throws at you. However, as we age, these cell signaling pathways begin to stop working as efficiently and ultimately the adaptive response slows.

Protandim NAD Synergizer was designed to target cell signaling pathways involved in the synthesis and recycling of a specific molecule called NAD (short for nicotinamide adenine dinucleotide). NAD is an essential molecule for many biochemical reactions in your body, most notably metabolism of the food we eat.

NAD coexists in your cells in two forms: 1) a molecule called NAD+ and 2) a molecule called NADH. It turns out, it is the ratio of these two forms of NAD (the so-called NAD+/NADH ratio) that is important for controlling a number of other cell signaling pathways. As the ratio of NAD+/NADH changes, NAD+ becomes a signaling molecule itself and is sensed by other proteins.

Under normal conditions, the cell very tightly regulates the NAD+/NADH ratio. However, changes in your metabolism like long- or short-term fasting can change this ratio. This means there is proportionately more NAD+ floating around the cell than NADH. This is biologically important because an increase in NAD+ has been shown to activate several key enzymes, and specifically a class of proteins called sirtuins.

Sirtuins have been implicated in a wide range of normal cellular processes including healthy aging, the body’s inflammatory response, and the cellular cleanup and renewal process known as autophagy to name a few. The absolute requirement of sirtuin activity for NAD links them directly to the metabolism of the cell. In fact, sirtuins have been shown to support longevity when caloric intake is drastically reduced. This is known as caloric restriction and is the only known way to nongenetically increase a healthy lifespan in mammals.

This is exactly the rationale behind Protandim NAD Synergizer formula. And because of this approach to nutrigenomically target a completely new set of cell signaling pathways significantly related to your overall health—and outside of the pathways targeted by Protandim NRF1 and Protandim Nrf2—is why Protandim NAD Synergizer is a perfect addition to the Protandim family of products.*

Ingredients

Wasabi (Wasabia japonica) Rhizome Powder

Wasabi, or Japanese horseradish, is a cruciferous vegetable that grows naturally in
shady and humid climates around the world. Extracts from the wasabi root (rhizome) are rich in isothiocyanates. Isothiocyanates have been shown to be potent activators of many different types of genetics and metabolic processes.*

Olive (Olea europaea) Leaf Extract

As the name suggests, olive leaf extract is derived from the leaves of the olive tree. Extracts from olive leaf contain many healthy compounds, most notably hydroxytyrosol. Hydroxytyrosol is a phenolic phytonutrient shown to have many health promoting activities such as supporting a healthy inflammation response, a healthy lipid profile (towards maintaining a healthy cholesterol level already within a normal range), and a healthy gut. It additionally supports gene expression, autophagy (or cellular cleanup), and antioxidant activity.*

Cuprous Niacin

Cuprous niacin is the complex between the vitamin niacin (vitamin B3) and the mineral copper but in its reduced or activated form. Copper is an essential cofactor for many physiological pathways including iron metabolism, nerve function, and energy production. Niacin is an important precursor for NAD synthesis. NAD is important to support energy production in the cell but also an essential cosubstrate for the family of enzymes known as sirtuins.*

Theacrine

Theacrine (1,3,7,9-tetramethyluric acid) is the predominant purine found in the tea Camellia kucha. It is psychostimulant structurally similar to caffeine. Theacrine’s multi-faceted effects come from the reactions between two neural pathways: dopaminergic and adenosinergic pathways. By affecting these major pathways, theacrine increases energy without irritability or habituation and helps enhance physical and mental performance.*